A mathematical model for pH-responsive ionically crosslinked TEMPO nanocellulose hydrogel design in drug delivery systems

Ionically crosslinked hydrogels based on TEMPO nanocelullose and alginate were prepared to develop a generalized pH value, temperature biopolymer concentration dependent mathematical model. The distinctive attention was in the demonstration of hydrogen bonds effects model, prevailing especially field low crosslink densities nanocellulose hydrogel acid medium. Accordingly, subjected research as comparable samples with less significant effect. equation built upon determination average mesh size network studying its changes different release environments. Based rheological measurements from basic acidic environment, mechanism swelling shrinkage thoroughly discussed well influence substituent groups, ionic interactions medium evaluated. Due protonation carboxylic shrink an environment. presented approach will accelerate, improve reduce cost controlled technology target drug delivery.